《大宅门》由郭宝昌出任编剧和导演，2001年荣获中央电视台收视冠军。 剧中讲述了医药世家白府经历清末、民国、军阀混战、解放等时期的浮沉变化，忠实地反映了同仁堂这个大家族随着国家、民族的历史发展而发展的渐变过程。故事横跨光绪年间、1900年八国联军侵入北京、1911年清朝覆灭、1931年九·一八事变、1937年七·七卢沟桥事变。官场恩怨、情场爱恨、商场输赢。谱写了一曲“宅门”史，展一幅波澜壮阔动荡社会生活画卷，父母子孙、妻妾丫妓、至爱亲朋；“宅门”人，谱一曲世态炎凉悲欢离合命运之歌。
This Chinese period drama series follows the fortunes of a prominent merchant family engaged in Traditional Chinese Medicine during the waning years of the Ching dynasty. The affairs of this family of doctors/pharmacists (which in those days were one and the same) are intimately linked with social upheavals of the time such as the encroachment of Christian missionaries and foreign imperialism as well as conflicts that inevitably emerge in a large upper class family. Comparable in scope and production value to such recent titles as "Downton Abbey", the lives and character of both masters and servants intertwine in plot lines that spans more than a generation.
郭宝昌：我与《大宅门》（转）。关于重看《大宅门》的一些新想法。白家为什么少不了白三爷。大宅门里德杨九红 悲剧。为杨九红，为何赛飞。八一八真实的大宅门。善因与善果—《大宅门》中的人生哲学。剧中前后的人物性格变化太大。死亡有多大。暗恋是一种病。
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