伊森（汤姆·克鲁斯 Tom Cruise 饰）曾是任职于特殊部门的秘密特工，自从一位名叫茱莉亚（米歇尔·莫娜汉 Michelle Monaghan 饰）的美丽女子出现在他的生命里后，伊森决定金盆洗手，卸甲归田。遗憾的是，好景不长，幸福的生活还没过多久，伊森便接到了徒弟林德赛（凯丽·拉塞尔 Keri Russell 饰）被死对头戴维恩（菲利普·塞默·霍夫曼 Philip Seymour Hoffman 饰）掳走的消息。戴维恩冷酷又凶残，林德赛落入他的手中可谓是凶多吉少。 　　为了解救林德赛，伊森重操旧业，他组织了一支精干的特工小组，向着目标人物发起了进攻。让伊森没有想到的是，戴维恩的真正目标并不是林德赛，而是茱莉亚，当爱妻落入敌手之时，伊森会做出怎样的反击？A man named Owen Davian kills an IMF agent that was sent undercover by the legendary Ethan Hunt, who has retired from combat missions. Hunt now has a fiancé, Julia, who believes that he works for the traffic department when he really trains younger IMF agents to go into combat. He is assigned to his last mission. His mission, should he choose to accept it is to capture Davian, who is selling a toxic weapon called the rabbits foot. But Davian is reckless, cruel, and deathly. He promises Hunt that he will find Julia, hurt her, and Ethan will be too dead to help her. The mission is no more different to others, its dangerous, smart, and impossible; but now it's personal.