《但丁密码》改编自丹·布朗2013年的小说《地狱》，讲述了符号学教授罗伯特·兰登（汤姆·汉克斯 Tom Hanks 饰）在意大利一所医院中醒来，发觉自己头部受到重创且失忆，同时还受到多组人马追杀，女医生西恩娜·布鲁克斯（费莉西蒂·琼斯 Felicity Jones 饰）帮助他逃出医院，寻回记忆，在这一过程中发现隐藏在但丁、米开朗琪罗等大师作品里的一个惊天阴谋，有极端邪恶的科学家妄图利用病毒把地球变成但丁《神曲》中描绘的地狱。Academy Award® winner Ron Howard returns to direct the latest bestseller in Dan Brown's (Da Vinci Code) billion-dollar Robert Langdon series, Inferno, which finds the famous symbologist (again played by Tom Hanks) on a trail of clues tied to the great Dante himself. When Langdon wakes up in an Italian hospital with amnesia, he teams up with Sienna Brooks (Felicity Jones), a doctor he hopes will help him recover his memories. Together, they race across Europe and against the clock to stop a madman from unleashing a global virus that would wipe out half of the world's population.