阿曼达（玛丽·玛特琳 Marlee Matlin饰），一位离婚的普通摄影师。她每日的生活平淡又死气沉沉，直到一日她经历了一段犹如“爱丽丝梦游仙境”般奇妙梦幻的时光。影片惊人的视觉特效让观众置身于阿曼达的神经世界里，一览微妙的细胞、分子甚至是量子世界。影片采访了多位著名学者，讨论关于真相、记忆、眼睛、大脑等深奥的话题。 　　本部标新立异、别出心裁的影片《我们到底知道多少？》，融合了纪实、剧情、视觉特效、动画等多种表现手法于一身，充满着量子论、物质、真理等一系列深奥玄妙的概念，构建出一个充满不确定性的量子世界。在这个看似稀松平常的未知领域里，到底何为真实。"WHAT THE #$*! DO WE KNOW?!" is a radical departure from convention. It demands a freedom of view and greatness of thought so far unknown, indeed, not even dreamed of since Copernicus. It's a documentary. It's a story. It's mind-blowing special effects. This film plunges you into a world where quantum uncertainty is demonstrated - where neurological processes, and perceptual shifts are engaged and lived by its protagonist - where everything is alive, and reality is changed by every thought.