故事发生在2008年，美国科学家从位于印度的丛林深处带回了一只巨大的雌性眼镜蛇，令科学家没有想到的是，这条眼镜蛇竟然化作了一位性感妖娆的美女（玛丽卡·沙拉瓦特 Mallika Sherawat 饰）。原来，这位美女就是印度神话传说中的蛇女神，她因阴险毒辣以人类为食而遭到了人类的敬畏和恐惧。如今，蛇女神再度出世，究竟是为了什么？ 　　经过了千难万险，蛇女神终于找到了她的目标——一条曾经和她交配过的雄性眼镜蛇，然而，此时的他早已经因为人类的迫害而奄奄一息。愤怒之火在蛇女神的内心里熊熊燃烧起来，她决心不惜一切代价，为自己的爱人报仇，人类的末日即将来临了。Desperate brain cancer-ridden Caucasian, George States, with only six months to live, decides to capture a male cobra with hopes of obtaining 'Nagmani' from the shape shifting Naga female. For reasons that remain obscure throughout the film this will not only cure his brain cancer but also make him immortal. He hires workers in the jungles of Natchi, Tamil Nadu, who witness the intimacy of the cobras, capture the male allowing the female to escape. George then holds the male cobra in a glass cage hoping that the female cobra will attempt a rescue, and he will then release it in exchange for the Nagamani. The region experiences horror and religious awakening after the enraged female cobra, with the image of its oppressor in its eyes, sheds its snake-skin and takes on a female human form, setting out on its deadly mission of tracking down and destroying her mate's oppressor, and whoever else gets in her way whether involved or not.