故事发生在遥远的未来，相貌平平的女孩朱庇特·琼斯（米拉·库尼斯 Mila Kunis 饰）自幼丧父，如今她以厕所清洁工的身份在茫茫人海中奋力求生。谁知毫无征兆的一天，朱庇特的命运彻底改变，来自外太空的“半兽人”赏金猎人凯恩（查宁·塔图姆 Channing Tatum 饰）将其劫持，而这一切都与朱庇特与生俱来的神秘基因有关。话说在浩瀚宇宙的最深处，存在着一个屹立数千亿年的埃布拉赛克斯王朝，在前代女王去世后，顺位第一继承人的巴勒姆（埃迪·雷德梅尼 Eddie Redmayne 饰）践祚，野心勃勃地开始了他的邪恶计划。但是朱庇特拥有和前代女王最为接近的血缘，从而对巴勒姆的王位构成了威胁。 　　原本肩负杀掉女孩重任的凯恩，在和朱庇特奔走在炮火砍杀的过程中，内心渐渐发生了变化……Jupiter Jones was born under a night sky, with signs predicting that she was destined for great things. Now grown, Jupiter dreams of the stars but wakes up to the cold reality of a job cleaning other people's houses and an endless run of bad breaks. Only when Caine Wise, a genetically engineered ex-military hunter, arrives on Earth to track her down does Jupiter begin to glimpse the fate that has been waiting for her all along - her genetic signature marks her as next in line for an extraordinary inheritance that could alter the balance of the cosmos.