臭名昭著的连环杀手Joe（杰姆斯·鲍弗 James Purefoy 饰）从死囚大牢逃走，再次大开杀戒，联邦调查局求助于退休探员Ryan Hardy（凯文·贝肯 Kevin Bacon 饰）。九年前，他曾亲手逮捕了谋杀了14名女学生的Joe。Hardy知道关于Joe的一切。但他现在的身份只是顾问，真正的主导力量是联邦调查局特别成立的专案组。成员包括对工作充满激情的女探员Jennifer（吉妮安·古森 Jeananne Goossen 饰）和思维敏锐的的Mike（肖恩·阿什莫 Shawn Ashmore 饰）。随着调查作的深入，Hardy发现Joe绑架了九年前谋杀未遂的受害人，想要完成当年没有完成的工作。但这次的对手不再是Joe一人，而是一群被相同的谋杀文化所驱策的变态杀人狂，一支“连环杀手军团”。最后的赢家会是谁呢？The FBI estimates there are currently over 300 active serial killers in the United States. What would happen if these killers had a way of communicating and connecting with each other? What if they were able to work together and form alliances across the country? What if one brilliant psychotic serial killer was able to bring them all together and activate a following?