比历史上任何的震颤、愉悦、高潮都强烈51倍的蓝色化合物，2千万的交易，为蓝色药丸疯狂的城市。这一切都开始于1971年，艾尔默·麦科尔罗伊(萨缪尔·杰克逊)毕业的当天，在开车回家的路上吸大麻被当场擒获，于是一眨眼的功夫，他的药剂师执照之梦，象他手里的青烟一样飘散了……Elmo McElroy is a streetwise American master chemist who heads to England to sell his special new formula - a powerful, blue concoction guaranteed to take you to 'the 51st state.' McElroy's new product delivers a feeling 51 times more powerful than any thrill, any pleasure, any high in history. But his plans for a quick, profitable score go comically awry when he gets stuck in Liverpool with an unlikely escort and his ex-girlfriend and becomes entangled in a bizarre web of double-dealing and double-crosses.