影片改编自同名畅销小说，故事讲述了在洛杉矶的拉古纳海滩，两个最要好的毒贩子Chon和Ben拒绝了墨西哥大毒枭为其卖命的要求，后者便绑架了二人的“红颜知己”Ophelia并索要一大笔赎金，为了救出女伴，他们偷偷盗取大毒枭自己的货物以换取赎金；真不啻是一场危险的角逐。In California, the former Navy SEAL Chon and his best friend, the peaceful botanist Ben, are successful entrepreneurs producing and dealing high-quality weed. Chon brought seeds from Afghanistan and Ben used his knowledge to develop the best marijuana in the country. Chon and Ben share the pothead lover Ophelia and she loves both of them since they complete each other - Chon is a powerful and strong lover and Ben is a sensible and loving lover. Their comfortable life changes when the Mexican Baja Cartel demands a partnership in their business. Chon and Ben refuse the deal and the leader of the cartel Elena sends her right-arm in America, Lado, to abduct Ophelia to press the American drug dealers. Chon and Ben ask the support of the dirty DEA Agent Dennis and get inside information to begin a secret war against the Baja Cartel to release Ophelia.