《丧尸围城：瞭望塔》的故事情节发生在大规模僵尸瘟疫爆发之后，政府研制的疫苗未能成功阻止病毒继续传播，弗兰克等四个主角一面要避开感染，一面要查找感染源头，但最终发现这一切竟是政府阴谋导致。In East Mission, Oregon, the Hit Point reporter Chase Carter and the camerawoman Jordan are covering stories from the people in quarantine of a zombie outbreak. The FEZA is using the vaccine Zombrex to inoculate the victims and Chase tries to interview Crystal LaRourke that is on the location. Out of the blue, the patients turn into zombies and Jordan flees with the Hit Point car, leaving Chase behind. He follows Crystal chased by zombies and she stumbles upon Maggie, a woman in shock that has just lost her daughter. They seek shelter in a loan store while Jordan arrives in the border but is sent to quarantine. While the military under the command of General Lyons want to bomb the city since Zombrex is ineffective, Chase, Crystal and Maggie fight to reach the border. Chase discovers a secret about Crystal while Jordan discloses the real intention of General Lyons.