故事描述一个普通家庭卷入一场巨大的政治阴谋——这起事件不仅改变了这家人的命运，也影响到国家安全。艾美奖得主Toni Collette（《塔拉合众国》）在该剧中扮演主人公Ellen，一个事业成功的华盛顿外科医生。美国政府挑选她为患病的总统实施手术，但她的家人突然遭到绑架，她意识到一场巨大的政治阴谋已经降临到自己头上。现在她必须小心考虑自己的选择，以最安全的方式救出丈夫和孩子。Dr. Ellen Sanders, a premiere surgeon, is thrust into a chilling political conspiracy when her family is taken hostage by rogue FBI Agent Duncan Carlisle. Ellen and her family are held captive in their home by Carlisle, a desperate man doing the wrong thing for the right reasons, who orders her to assassinate the President when she operates on him. His highly skilled accomplices include his brother-in-law Kramer, whose loyalty to Carlisle will be tested; quick-tempered and intimidating Archer, an ex-military man with a razor-sharp tongue; and the only woman involved, Sandrine, a mysterious last-minute replacement to the team. With her family's life in peril, Ellen faces an incomprehensible moral dilemma in order to save her overbearing husband Brian, her secretive daughter Morgan and her not-so-innocent son Jake. In this high-stakes standoff between Ellen and Carlisle, fraught with tremendous national and personal consequences, the choices between right and wrong become even more blurred.