性感美丽的雪莉·达灵顿（安娜·法瑞丝 Anna Faris 饰）曾是一名隶属于《花花公子》旗下的兔女郎，在27岁之前，她过着奢华无忧的快乐生活。然而就在27岁生日的第二天，她却被老板扫地出门。无所依靠且别无所长，雪梨漫无目的四处游走，偶然加入了由莫娜（凯特·戴琳斯 Kat Dennings 饰）、娜塔丽（艾玛·斯通 Emma Stone 饰）等女孩组成的女子联谊会Zeta Alpha Zeta，这些女孩穿着老土、性格怪异，在学校内其他团体的眼里如同怪胎。雪梨的到来有如一支催化剂，她利用自己丰富的经验帮助女孩们改变造型，打造吸引男性眼球的外形和气质，原本无人问津的女孩开始受到追捧，而雪梨也收获了属于自己的爱情……Finding family. Shelley Darlingson was raised in an orphanage, finally happy when she blossoms into a fox and moves into the Playboy Mansion. Unfortunately, she's summarily expelled on her 27th birthday(she's now too old). In desperation she takes a job as house mother for a sorority of misfits losing their house for lack of members. They have but a few months to find 30 pledges, or a sorority of mean girls will take over their place. Shelley figures that girls will pledge a house that boys find interesting, so she sets out to make the Zetas alluring, not act too smart, and host great parties. Can she succeed, and what about her own makeover? Sabotage is everywhere, plus it's hard to be one's self.