联调局学院学员 Clarice M. Starling（乔迪·福斯特 饰）受行为科学组的 Jack Crawford（斯科特·格伦 饰）指派，前往州立巴尔的摩法医院访问被监禁的精神科医生 Hannibal Lecter（安东尼·霍普金斯 饰）。Lecter要求转到条件较 好的联邦机构，远离常常折磨他的 Frederick Chilton 医生（安东尼·希尔德 饰），并愿意为此提供持续作案的连环杀手水牛比尔（泰德·莱文 饰）的心理分析……FBI trainee Clarice Starling works hard to advance her career, including trying to hide or put behind her West Virginia roots, of which if some knew would automatically classify her as being backward or white trash. After graduation, she aspires to work in the agency's Behavioral Science Unit under the leadership of Jack Crawford. While she is still a trainee, Crawford does ask her to question Dr. Hannibal Lecter, a psychiatrist imprisoned thus far for eight years in maximum security isolation for being a serial killer, he who cannibalized his victims. Clarice is able to figure out the assignment is to pick Lecter's brains to help them solve another serial murder case, that of someone coined by the media as Buffalo Bill who has so far killed five victims, all located in the eastern US, all young women who are slightly overweight especially around the hips, all who were drowned in natural bodies of water, and all who were stripped of large swaths of skin. She also figures that Crawford chose her as a woman to be able to trigger some emotional response from Lecter. After speaking to Lecter for the first time, she realizes that everything with him will be a psychological game with her having often to read between the very cryptic lines he provides. She has to decide how much she will play along as his request in return for talking to him is to expose herself emotionally to him. The case takes more dire turns when a sixth victim is discovered, this one from who they are able to retrieve a key piece of evidence if Lecter is being forthright as to its meaning. A potential seventh victim is high profile Catherine Martin, the daughter of Senator Ruth Martin, which places greater scrutiny on the case as they search for a hopefully still alive Catherine. Who may factor into what happens is Dr. Frederick Chilton, the warden at the prison, he an opportunist who sees the higher profile with Catherine, meaning a higher profile for himself if he can insert himself successfully into the proceedings.