前美国大兵雷蒙德·盖恩斯（道恩·强森 Dwayne Johnson 饰）在结束硝烟战火的生涯后，而今成为洛杉矶消防局的直升机救援人员。虽然工作中全力以赴，受人敬仰，值得信赖，这些却都无法挽回他失败的婚姻。某次短暂休假后，雷重返岗位，这时在内华达州南部发生了百年不遇的大地震，胡佛水坝在强震中被彻底摧毁。未过多久，又一轮强震从旧金山袭向了洛杉矶，雷在直升机上目睹了繁华城市转眼变成废墟的可怕一幕。 　　此时他的妻子艾玛（卡拉·古奇诺 Carla Gugino 饰）和女儿布蕾克（亚历珊德拉·达达里奥 Alexandra Daddario 饰）此时分处两座城市，为了拯救最爱的两个人，他只身一人，勇往直前，与地震展开争分夺秒的赛跑……In San Andreas, California is experiencing a statewide earthquake that goes on record as easily the biggest earthquake in history. Dwayne Johnson plays Ray Gaines, a helicopter rescue pilot for the Los Angeles Fire Department, who is trying to find his daughter, Blake (Alexandra Daddario), who is in San Francisco amidst the chaos. Ray's estranged wife, Emma, is forced to turn to Ray for help, as he is her last resort. Together they journey to save their daughter.