数月前军情六处一块记载了潜伏于全世界恐怖组织内部所有特工名单信息的硬盘丢失，而追索硬盘的行动也以失败告终。在此之后，行动主要负责人M（朱迪·丹奇 Judi Dench 饰）被高层解雇，而军情六处也遭到惨烈的袭击，伤亡惨重。为了查到幕后真凶，M召来佯死的传奇特工詹姆士·邦德（丹尼尔·克雷格 Daniel Craig 饰）。经过一轮严苛的特训和测试，邦德重新服役。在伊芙（娜奥米·哈里斯 Naomie Harris 饰）和新搭档Q（本·卫肖 Ben Whishaw 饰）的协助下，邦德追寻着某前CIA特工的踪迹来到繁华大都会上海。 　　在这一过程中，特工的名单不断泄露，而邦德最新一次的生死冒险也拉开序幕……When Bond's latest assignment goes gravely wrong and agents around the world are exposed, MI6 is attacked forcing M to relocate the agency. These events cause her authority and position to be challenged by Gareth Mallory (Ralph Fiennes), the new Chairman of the Intelligence and Security Committee. With MI6 now compromised from both inside and out, M is left with one ally she can trust: Bond. 007 takes to the shadows - aided only by field agent, Eve (Naomie Harris) - following a trail to the mysterious Silva (Javier Bardem), whose lethal and hidden motives have yet to reveal themselves.