在亚当（阿什顿•库奇 Ashton Kutcher 饰）的成长经历中，艾玛（娜塔丽•波特曼 Natalie Portman 饰）总是时不时的出现，所以两个人可以算是朋友。一次，亚当探望自己明星父亲时发现，父亲居然和自己的前女友同居了，这让亚当无论如何也不能接受，在遭遇情感的重创之后，亚当决定要随便找一个女性朋友上床发泻抑郁。宿醉的亚当醒来之后，发现自己居然裸着身体在艾玛家里，在达成“只谈性不谈爱”的协议之后，两人便开始时不时的幽会。随着时间的推移，亚当发现自己似乎对身边这个特立独行的女孩动了心，但是艾玛却表示不能接受亚当的爱意，所以他们最终决定结束这种关系。但是，分手之后二人才发现，他们早已习惯了彼此……Occasionally in the 15 years since summer camp, Adam and Emma cross paths. When he discovers that an ex-girlfriend is living with his dad, he gets drunk, calls every woman in his cell phone contact list, and ends up passed out naked in her living room. By this time, she's a medical resident in L.A. and he's a gopher on a "Glee"-like TV series, hoping to be a writer. She guards her emotions (calling her father's funeral "a thing"), so after a quick shag in the moments she has before leaving for the hospital, she asks if he wants a no-strings-attached, sex-only relationship, without romance or complications. A prescription for fun or for disaster?