一枚金币让探险家德克（马修·麦康纳 Matthew McConaughey饰）兴趣盎然，因为金币与某个宝藏传说有着千丝万缕的联系。而德克是个极喜冒险、一刻也停不下来的人，他在西非尼日尔河一带展开了一段曲折的探险之旅，关于这枚金币的秘密层层剥开。更为关键的是，他还发现了一个 足以危害人类毁灭地球的大危机——非洲一个独裁政权和当地富豪勾结，把核原料大量倾倒在海洋中。当地的人民已经深受其害，神志癫狂，如果不及时出手，危难将会迅速扩大。 　　德克和女科学家伊娃（佩内洛普·克鲁兹 Penélope Cruz饰），共同展开了一场正义的斗争。他们要面对恶势力和艰险的自然环境，一路险相横生。Master explorer and former US Navy Seal Dirk Pitt and his wisecracking buddy Al Giordino goes on the adventure of a lifetime of seeking out a lost Civil War ironclad battleship known as the "Ship of Death" that protects a secret cargo is lost somewhere in the deserts of West Africa. But while the two cross paths with a beautiful and brilliant U.N. scientist Dr. Eva Rojas who is being hounded by a ruthless dictator. She believes that the hidden treasure may be connected to a larger problem that threatens the world around them. Hunting for a ship that no one else thinks exists, Dirk, Al, and Eva must rely on their wits and their daring heroics to outsmart dangerous warlords, survive the threatening terrain, and get to the bottom of both mysteries.