故事发生在阳光旅馆的10号房，这是一个神奇的房间，其中发生的事情早已经脱离了能够用科学解释的范畴。这个房间里，每一样物品都被赋予了一种特殊的能力，拥有了一件物品，就能够随心所欲的使用它的能力。当这个消息不胫而走的时候，各路人士怀揣着各种各样的目的从世界各地聚集到了10号房间，然而他们并不知道的事，得到就要付出，这付出可能是身体上的、感情上的，也有可能是生命。 　　一次偶然中， 警察米勒（彼得·克劳斯 Peter Krause 饰）得到了一把神秘的钥匙，而这把钥匙正归属于10号房间，与此同时，米勒的女儿亦在房间里无故失踪，为了找到心爱的女儿，米勒踏上了充满危险和劫难的旅程。Detective Joe Miller comes into possession of a seemingly innocuous motel room key while working on a murder case. The key can open every door and take him into a motel room that seems to exist outside of normal time and space. However, if he leaves something in the motel room that did not originally come from there, it will be gone as soon as the room "resets"... He discovers that there are special objects hidden in different places. They don't look special, but they have special powers. When his daughter disappears and he is framed for killing his partner, he must find a way to bring her back from the room, while working with different groups and people searching for the objects. But who can he really trust when everyone goes crazy after touching the objects...