卡索(约翰尼·德普 Johnny Depp 饰)着迷于收藏离奇古怪的珍稀书籍。这种才华令富翁巴尔坎（弗兰克·兰格拉 Frank Langella 饰）大为赏识。他派给卡索一个艰巨的任务——寻找一本叫《第九道门》的古书，并鉴定他手中那本的真假。这本书在世界上仅存3本，剩下的两本，分别流落到了葡萄牙和法国。 　　传说，只要通读此书，就可以召唤魔鬼的到来。卡索开始了曲折而又魔幻的寻找历程。他探访了书的原主人之妻、古籍修缮专家、遇上绿眼珠的神秘女人，期间他朋友的暴毙竟然跟书里的插图如出一辙，命案还在连连上演。原来，书中所带的咒语，恐怕会使得拥有者无一幸免。而如果三本书合在了一起，就会迎来邪恶的撒旦。而到底最终魔鬼的脸有没有出现？In New York, the money-driven dealer Dean Corso is a rare-books expert and partner of Bernie, who owns a bookstore. He is contacted by the renowned collector of books about the devil Boris Balkan, who has just acquired the rare The Nine Gates of the Kingdom of Shadows from the collector Andrew Telfer, to verify whether his book is authentic or a forgery. Balkan explains that the book was written by the writer Aristide Torchia, in 1666, with Lucifer and he was burned at the stake with his entire work. There are only three exemplars of The Nine Gates and in accordance with the legend, its nine engravings form a riddle to conjure the devil. The skeptical Corso accepts the assignment and has to fly to Sintra, Portugal, and Paris, France, to contact the owners Victor Fargas and Baroness Kessler and find the genuine exemplar for Balkan. Meanwhile, he asks Bernie to hide the rare book. Before traveling to Europe, the widow Liana Telfer wants to retrieve the book and has sex with Corso, but he does not accept her offer. When Corso returns to Bernie's bookstore, he finds his friend murdered in the same position of an engraving. Corso travels to Toledo, Spain, to meet the Ceniza twin brothers and learn more about The Nine Gates. During his journey in Europe, Corso is pursued by Liana and her bodyguard, who belong to the sect The Order of the Silver Serpents, and is protected by a mysterious Girl with supernatural powers. Meanwhile, the owners of the two other exemplars of The Nine Gates are murdered. Corso becomes obsessed with the book and discloses the truth about it.