一切源自于无处不在的寂寞。当寂寞蔓延到头顶无法呼吸，过气电视明星鲍勃·哈里斯(比尔·默瑞 Bill Murray 饰)，已为人妻的夏洛特(斯嘉丽·约翰逊 Scarlett Johansson 饰)，年轻貌美的电影女演员凯莉(安娜·法瑞丝 Anna Faris 饰)在机缘巧合下在东京相遇。在这个不是故乡的陌生城市里，他们在豪华旅馆邂逅，不约而同的失眠，互相 陪伴，生活一方面仿佛变的缤纷起来，另一面却逐渐走向迷失，过气明星和为人妻的夏洛特能迎接他们二人思想和关系变化的挑战吗？冲破迷失或者身陷其中，让我们一起找寻答案。Middle-aged American movie star Bob Harris is in Tokyo to film a personal endorsement Suntory whiskey ad solely for the Japanese market. He is past his movie star prime, but his name and image still have enough cachet for him to have gotten this lucrative $2 million job. He has an unsatisfying home life where his wife Lydia follows him wherever he goes - in the form of messages and faxes - for him to deal with the minutiae of their everyday lives, while she stays at home to look after their kids. Staying at the same upscale hotel is fellow American, twenty-something recent Yale Philosophy graduate Charlotte, her husband John, an entertainment still photographer, who is on assignment in Japan. As such, she is largely left to her own devices in the city, especially when his job takes him out of Tokyo. Both Bob and Charlotte are feeling lost by their current situations, which are not helped by the cultural barriers they feel in Tokyo, those cultural barriers extending far beyond just not knowing the language. After a few chance encounters in the hotel, they end up spending much of their time hanging out together, each helping the other deal with their feelings of loss in their current lives. The friendship that develops between the two, which is not always a bumpy-free one, may be just for this specific place and time, but it may also have long lasting implications.