This series is set after the events of Terminator 2: Judgment Day (1991). After the sacrifices of Dr. Miles Dyson and T-800 Model 101 Terminator, the Connors find themselves once again being stalked by Skynet's agents from the future. Realizing their nightmare isn't over, they decide to stop running and focus on preventing the birth of Skynet. With the aid of Cameron Phillips, a beautiful girl who has a mysterious past also linked to the future; Derek Reese, a Tech-Com soldier from the future whose past is linked with the Connors; Riley, a beautiful schoolfriend of John; and FBI Agent James Ellison, who was assigned to capture the Connors but joins them after his own encounter with one of the machines. They begin a quest to stop the United States military and a shadowy conspiracy from the future from creating the program that will stop at nothing to bring humanity to an end.