来自克里夫兰的美国小伙子威廉•布莱克（约翰尼•德普 Johnny Depp 饰）往西部去讨生活，他准备前往当地的一间工厂应聘会计。不料，他错过了应聘时间，被赶了出来。还遭到了当地迪金森金属厂的老板的百般凌辱，甚至被枪指着脑袋。 　　当他沮丧地来到当地的小酒馆，一夜情发生了。岂料，和他发生一夜情的女子的男友突然闯了进来，子弹穿过女子的胸膛嵌在了威廉的胸膛上，威廉本能之下杀死了女子的男友，夺了他的马匆匆逃走了。 　　一段充满了惊险、追杀的逃亡之旅开始了……Dead Man is the story of a young man's journey, both physically and spiritually, into very unfamiliar terrain. William Blake travels to the extreme western frontiers of America sometime in the 2nd half of the 19th century. Lost and badly wounded, he encounters a very odd, outcast Native American, named "Nobody", who believes Blake is actually the dead English poet of the same name. The story, with Nobody's help, leads William Blake through situations that are in turn comical and violent. Contrary to his nature, circumstances transform Blake into a hunted outlaw, a killer, and a man whose physical existence is slowly slipping away. Thrown into a world that is cruel and chaotic, his eyes are opened to the fragility that defines the realm of the living. It is as though he passes through the surface of a mirror, and emerges into a previously-unknown world that exists on the other side.