一次偶然中，蓝妹妹（黛米·洛瓦托 Demi Lovato 配音）发现了一张遗落的地图，指引向一座神秘的村庄。为了求证村庄存在的真实性，蓝妹妹和好友聪聪（丹尼·普迪 Danny Pudi 配音）、健健（乔·曼根尼罗 Joe Manganiello 配音）、笨笨（杰克·麦克布瑞尔 Jack McBrayer 配音）一起踏上了旅途。 　　一路上，初出茅庐的四人组遭遇了无数的危险，但总能凭借他们的智慧和运气化险为夷，四人的友情亦遭到了重重考验。邪恶的格格巫（雷恩·威尔森 Rainn Wilson 配音）也知晓了村庄的存在，为了第一个到达村庄，格格巫开始千方百计的阻挠起蓝妹妹一行的前途。In this fully animated, all-new take on the Smurfs, a mysterious map sets Smurfette and her best friends Brainy, Clumsy and Hefty on an exciting and thrilling race through the Forbidden Forest filled with magical creatures to find a mysterious lost village before the evil wizard Gargamel does. Embarking on a roller-coaster journey full of action and danger, the Smurfs are on a course that leads to the discovery of the biggest secret in Smurf history!