伊森·亨特（汤姆·克鲁斯饰）和队友们接到了追回三个大杀伤性核武器的任务。眼见任务马上就能完成，但为了挽救其中一位队友卢瑟（文·瑞姆斯饰）的生命，三个核武器被人趁机带走。中情局负责人斯隆女士（安吉拉·贝塞特饰）调来她手下的得意猛将沃克（亨利·卡维尔饰），让他盯着伊森·亨特完成追回核武器的任务。期间，女特工伊尔莎（丽贝卡·弗格森饰）突然出现，伊森·亨特发现，他要面对的并不只是恐怖分子，还有潜藏在政府部门的内鬼。Two years after Ethan Hunt had successfully captured Solomon Lane, the remnants of the Syndicate have reformed into another organization called the Apostles. Under the leadership of a mysterious fundamentalist known only as John Lark, the organization is planning on acquiring three plutonium cores. Ethan and his team are sent to Berlin to intercept them, but the mission fails when Ethan saves Luther and the Apostles escape with the plutonium. With CIA agent August Walker joining the team, Ethan and his allies must now find the plutonium cores before it's too late.