本片是完全原创故事，超级英雄们不再是熟悉的样子，超人成为了佐德的儿子，蝙蝠侠成为吸血鬼，神奇女侠是“新神”，正义联盟为了摆脱被诽谤的罪名对科学家遇害事件展开调查。In an alternate universe, Superman is the son of Zod and was raised by a caring couple of Mexican immigrants living in harsh conditions, Batman is a young vampiric doctor, Kirk Langstrom, obsessed with an everlasting search for a cure for his disease and Wonder Woman is Bekka, the widowed queen of the world of Darkside. The three antiheroes unite and create the Justice League, despite wheelchair-bound Lex Luthor and others' protests. They operate often outside of the law and often kill the villains, but the US government tolerates them and works with them to an extent, since the three are willing to cooperate with the authorities and they never kill civilians. However, the all out paranoia and protests against their methods and untouchable position are growing. Things take a turn for the worse, when they are framed for a series of murders of famous scientists, who work for the government, and President Amanda Waller orders their arrest. They decide to violently resist arrest at all cost, until they can find the real culprits themselves.